tailieunhanh - Báo cáo y học: "High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research. | Open Access High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri a new vertebrate model for aging research Kathrin Reichwald Chris Lauber Indrajit Nanda Jeanette Kirschner Nils Hartmann Susanne Schories Ulrike Gausmann Stefan Taudien Markus B Schilhabel Karol Szafranski Gernot Glockner Michael Schmid Alessandro Cellerino Manfred Schartl Christoph Englert and Matthias Platzer Addresses Leibniz Institute for Age Research - Fritz Lipmann Institute Beutenbergstr. 07745 Jena Germany. Department of Physiological Chemistry I University of Wurzburg Biozentrum Am Hubland 97074 Wurzburg Germany. Department of Human Genetics University of Wurzburg Biozentrum Am Hubland 97074 Wurzburg Germany. Current address Department of Medical Microbiology Leiden University Medical Centre 2300 RC Leiden The Netherlands. Current address Institute of Clinical Molecular Biology University Hospital Schleswig-Holstein Campus Kiel Schittenhelmstr. 24105 Kiel Germany. Correspondence Kathrin Reichwald. Email kathrinr@ Published II February 2009 Genome Biology 2009 10 RI6 doi gb-2009- I0-2-rI6 The electronic version of this article is the complete one and can be found online at http content I0 2 RI6 Received I December 2008 Revised 26 January 2009 Accepted II February 2009 2009 Reichwald et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The annual fish Nothobranchius furzeri is the vertebrate with the shortest known life span in captivity. Fish of the GRZ strain live only three to four months under optimal laboratory conditions show explosive growth early sexual maturation and age-dependent physiological and behavioral decline and express aging related