tailieunhanh - Báo cáo y học: "Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. | Research Open Access Distinct transcriptional MYCN c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas Frank WestermannH Daniel MuthH Axel Benner Tobias Bauer Kai-Oliver Henrich André Oberthuer Benedikt Brors Tim Beissbarth Jo Vandesompele Filip Pattyn Barbara Hero Rainer Konig Matthias Fischer and Manfred Schwab Addresses Department of Tumor Genetics German Cancer Research Center Im Neuenheimer Feld 280 Heidelberg 69120 Germany. Department of Biostatistics German Cancer Research Center Im Neuenheimer Feld 280 Heidelberg 69120 Germany. Theoretical Bioinformatics German Cancer Research Center Im Neuenheimer Feld 280 Heidelberg 69120 Germany. Department of Pediatric Oncology University Children s Hospital of Cologne Kerpener Strasse 62 Cologne 50924 Germany. Division of Molecular Genome Analysis German Cancer Research Center Im Neuenheimer Feld 580 Heidelberg 69120 Germany. Center for Medical Genetics Ghent University Hospital De Pintelaan 185 Ghent 9000 Belgium. H These authors contributed equally to this work. Correspondence Frank Westermann. Email Published 13 October 2008 Genome Biology 2008 9 R150 doi gb-2008-9- 10-r 150 The electronic version of this article is the complete one and can be found online at http 2008 9 10 R150 Received 6 August 2008 Revised 19 September 2008 Accepted l3 October 2008 2008 Westermann et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20 of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy neuroblastomas elevated MYCN mRNA and protein levels are .