tailieunhanh - Báo cáo y học: "Comparative phosphoproteomics reveals evolutionary and functional conservation of phosphorylation across eukaryotes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative phosphoproteomics reveals evolutionary and functional conservation of phosphorylation across eukaryotes. | Open Access Research Comparative phosphoproteomics reveals evolutionary and functional conservation of phosphorylation across eukaryotes Jos Boekhorst Bas van Breukelen Albert JR Heck and Berend Snel Addresses Bioinformatics Department of Biology Faculty of Science Utrecht University Padualaan 3584 CH The Netherlands. tBiomolecular Mass Spectrometry and Proteomics Group Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences Utrecht University Sorbonnelaan 3584 CA Utrecht The Netherlands. Academic Biomedical Centre Utrecht University Yalelaan 3584 CL Utrecht The Netherlands. Correspondence Jos Boekhorst. Email Published I October 2008 Genome Biology 2008 9 RI44 doi gb-2008-9- I0-r I44 The electronic version of this article is the complete one and can be found online at http 2008 9 I0 RI44 Received 8 July 2008 Revised 3 September 2008 Accepted I October 2008 2008 Boekhorst et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Reversible phosphorylation of proteins is involved in a wide range of processes ranging from signaling cascades to regulation of protein complex assembly. Little is known about the structure and evolution of phosphorylation networks. Recent high-throughput phosphoproteomics studies have resulted in the rapid accumulation of phosphopeptide datasets for many model organisms. Here we exploit these novel data for the comparative analysis of phosphorylation events between different species of eukaryotes. Results Comparison of phosphoproteomics datasets of six eukaryotes yields an overlap ranging from approximately 700 sites for human and mouse two large datasets of closely related species to a single site for