tailieunhanh - Báo cáo sinh học: "Resistance to experimental infections with Haemonchus contortus"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Resistance to experimental infections with Haemonchus contortus | Genet Sei Evol 1990 22 205-229 Elsevier INRA 205 Original article Resistance to experimental infections with Haemonchus contort US in Romanov sheep G Luffau1 J Vu Tien Khang2 J Bouix2 TO Nguyen3 p Cullen4 G Ricordeau2 with the technical assistance of c Carrat F Eychenne Institut National de la Recherche Agronomique 1 Station de Virologie et d lmmunologie Centre de Recherches de Jouy-en-Josas 78350 Jouy-en-Josas s Station d Amelioration Génétique des Animaux Centre de Recherches de Toulouse BP 27 31326 Castanet- Tolosan Cedex sLaboratoire des Groupes Sanguins Centre de Recherches de Jouy-en-Josas 78350 Jouy-en-Josas Laboratoire de Génétique Biochimique Centre de Recherches de Jouy-en-Josas 78350 Jouy-en-Josas France Received 22 August 1989 accepted 28 February 1990 Summary - Responses to immunization with aggregated human serum albumin HSA and to repeated experimental infections with H contortusiwere studied in 51 female lambs of the RomanovI breed born from 8 sires and 36 dams. The 8 sires were of haemoglobin genotype Hb AB the 51 lambs were distributed into 3 groups of 17 each corresponding to the 3 genotypes HbAA HbAB and HbBB. In addition the experimental lambs were typed for antigens of the major histocompatibility system OLA . The parasitological findings were the following a repeatability of faecal egg counts between successive infections a negative correlation between peak faecal egg counts and self-cure intensity a positive correlation between faecal egg counts and degree of anaemia an acquisition of immunity to the parasite by previous contact with the parasite and a reduction of this immunity by anthelmintic treatment. According to the genetic investigations there were significant sire effects on variables reflecting the resistance. The faecal egg counts did not seem to be related to the haemoglobin system but might be affected by 1 or several genes located in the OLA complex or close to the latter. The humoral response to HSA showed a negative .

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