tailieunhanh - Báo cáo sinh học: "Mechanisms of resistance to acrolein in Drosophila melanogaster"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Mechanisms of resistance to acrolein in Drosophila melanogaster | Genet. Sei. Evol. 1989 21 427-436 Elsevier INRA 427 Original article Mechanisms of resistance to acrolein in Drosophila melanogaster . Sierra . Comendador and I. Aguirrezabalaga University of Oviedo Area of Genetics Department of Functional Biology 33071 Oviedo Spain received 29 November 1988 accepted 26 May 1989 Summary - The mechanisms of acrolein resistance developed by 2 D. melanogaster lines have been studied. The results suggest that there are 2 overlapping mechanisms. One of them is a reduction of breathing requirements which reduces the amount of acrolein entering the flies and the other is an increase in aldehyde dehydrogenase activity probably the first is the more important. acrolein resistance mechanisms toxic tolerance Drosophila melanogaster Resume Mécanismes de resistance à 1 acroléine chez Drosophila melanogaster. Dans ce travail on a étudié les mécanismes de resistance à 1 acroléine qu ont développés 2 souches de D. melanogaster. Les résultats suggerent existence de 2 mécanismes superposes. L un des 2 se présente comme une reduction des exigences respiratoires ce qui réduit 1 entrée d acroleine dans I organisme. L autre montre une elevation de 1 activité aldehyde deshydrogenase. Le premier mécanisme est probablement le plus important. acroléine - mécanismes de resistance - tolerance aux toxiques - Drosophila melanogaster INTRODUCTION Two main mechanisms of chemical resistance have been described in Drosophila - an increase in detoxification through the metabolic degradation of the toxin Togby et al. 1976 McDonald et al 1977 Kamping and Van Delden 1978 O Byrne-Ring and Duke 1980 for which an increase in the production of the implicated enzyme or enzymes is necessary - a modification or alteration in the enzyme action site for which the toxin is the target Morton and Singh 1982 . Apart from these 2 other mechanisms have been described in other insects like Musca domestica which avoid absorption of the toxin by the action of a single gene Plapp