tailieunhanh - Chronic Kidney Disease in Southwestern Iranian Children 

CKD in children is the result of heterogeneous diseases of the kidney and urinary tract that range from common congenital malformations of the urinary tract, to rare inborn errors of metabolism that affect kidney function[1] . CKD is an irreversible condition that eventually progresses to end stage renal disease (ESRD). It is an important cause of morbidity and mortality in children worldwide [2,3] . The causes of CKD vary from one geographic area to another due to genetic and environmental factors. Some of these causes are preventable while in others, appropriate medical treatment and interventions may retard the progression of the disease [2] . In the absence of a national registry, there is paucity of information regarding the etiology of CKD in children from Iran[4] . An understanding of the causes of CKD is important as it may guide the distribution of limited resources towards its prevention. The aim of the present study was to determine retrospectively the etiology of CKD in children referred to our center. . | Original Article Iran J Pediatr Jun 2009 Vol 19 No 2 Pp 147-153 Chronic Kidney Disease in Southwestern Iranian Children Ali Ahmadzadeh 1 MD Ehsan Valavi1 MD Mehrnaz Zangeneh-Kamali1 MD Azin Ahmadzadeh1 MD 1. Department of Pediatrics Ahvaz University of Medical Sciences Ahvaz IR Iran Received Sep 03 2008 Final Revision Dec 01 2008 Accepted Jan 23 2009 Abstract Objective The aim of the study was to determine the etiology of Chronic Kidney Disease CKD among children attending the pediatric nephrology service at Abuzar children s hospital in Ahvaz city the referral center in Southwest of Iran. Methods We reviewed the records of 139 children diagnosed to have CKD over a 10-year period. CKD was defined a glomerular filtration rate GFR below 60 ml m2 min persisting for more than 3 months. Findings Among 139 children 81 58 were males. The mean age at diagnosis of CKD in the patients was years. Mean level of serum creatinine at presentation was mg dl. The mean GFR at presentation was ml min while 22 of the patients were already at end stage renal failure indicating that these children were referred too late. Congenital urologic malformation was the commonest cause of CKD present in 70 children reflux nephropathy hypo dysplastic kidney obstructive uropathy and prune belly syndrome . Other causes included hereditary nephropathies chronic glomerulo-nephritis multisystemic diseases miscellaneous and unknown each one . The mean duration of follow-up was 26 months. Peritoneal or hemodialysis was performed in 10 patients. Six patients underwent 4 live-related and 2 non-related renal transplantation. The rest have died or received standard conservative management for CKD. Conclusion The commonest causes of CKD were reflux nephropathy hypo dysplastic kidney hereditary nephropathy and obstructive uropathy. Patients presented late had severe CKD and were malnourished and stunted. Iranian Journal of .

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