tailieunhanh - Báo cáo hóa học: " Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1"

Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1 | Ricci et al. Journal of Translational Medicine 2010 8 49 http content 8 1 49 RESEARCH JOURNAL OF TRANSLATIONAL MEDICINE Open Access Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1 Elisabetta Ricci 1 Sandro Malacrida2 Marisa Zanchetta3 Ilaria Mosconi1 Marco Montagna3 Carlo Giaquinto4 and Anita De Rossi 1 3 Abstract Background Toll-like receptors TLRs recognize pathogen-associated molecular patterns and play a crucial role in the host s innate immune response. Genetic variations in TLR genes may influence host-viral interactions and might impact upon the risk of mother-to-child transmission MTCT of Human Immunodeficiency Virus type 1 HIV-1 . The aim of this study was to investigate the influence of genetic variants of TLR 9 gene on MTCT. Methods Three hundred children 118 HIV-1-infected and 182 HIV-1-uninfected born to HIV-1-infected mothers were studied. Single nucleotide polymorphisms SNPs NM A rs352139 and G rs352140 of the TLR9 gene were genotyped by TaqMan allelic discrimination assay. Statistical analyses were performed using SNPStats program. Results When considered separately neither of the two SNPs was significantly associated with risk of HIV-1 infection. However the A A and G G haplotypes were associated with a higher risk of HIV-1 infection compared to the prevalent G A haplotype odds ratio OR 95 confidence interval CI p and OR 95 CI p respectively . Conclusions Overall results demonstrate a significant correlation between specific genetic variants of the TLR9 gene and risk of MTCT of HIV-1 thus confirming a critical role of innate immunity in perinatal HIV-1 infection. Strategies aimed at modulating innate immunity might be useful for future treatment of pediatric HIV-1 infection and AIDS. Background Mother-to-child transmission MTCT is the main source of pediatric HIV-1 infection. MTCT of .