tailieunhanh - Báo cáo sinh học: " A trial of somatic gene targeting in vivo with an adenovirus vector"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: A trial of somatic gene targeting in vivo with an adenovirus vector | Genetic Vaccines and Therapy BioMed Central Research Open Access A trial of somatic gene targeting in vivo with an adenovirus vector Asami Ino1 2 Yasuhiro Naito1 3 Hiroyuki Mizuguchi4 Naofumi Handa1 Takao Hayakawa5 and Ichizo Kobayashi 1 2 Address Department of Medical Genome Sciences Graduate School of Frontier Science University of Tokyo Institute of Medical Science University of Tokyo 4-6-1 Shirokanedai Minato-ku Tokyo 108-8639 Japan 2Graduate Program in Biophysics and Biochemistry Graduate School of Science the University of Tokyo 3Department of Environmental Information Keio University 5322 Endo Fujisawa Kanagawa 2528520 Japan 4Laboratory of Gene Transfer and Regulation National Institute of Biomedical Innovation Asagi 7-6-8 Saito Ibaraki Osaka 5670085 Japan and 5Pharmaceuticals and Medical Devices Agency Shin-Kasumigaseki Bldg. 3-3-2 Kasumigaseki Chiyoda-ku Tokyo 100-0013 Japan Email Asami Ino - ino@ Yasuhiro Naito - ynaito@ Hiroyuki Mizuguchi - mizuguch@ Naofumi Handa - nhanda@ Takao Hayakawa - hayakawa-takao@ Ichizo Kobayashi - ikobaya@ Corresponding author Published 12 October 2005 Received 01 July 2005 Genetic Vaccines and Therapy 2005 3 8 doi 1479-0556-3-8 Accepted 12 October 2005 This article is available from http content 3 1 8 2005 Ino et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gene targeting in vivo provides a potentially powerful method for gene analysis and gene therapy. In order to sensitively detect and accurately measure designed sequence changes we have used a transgenic mouse system MutaMouse which has been developed for detection of mutation in vivo. It carries .