tailieunhanh - báo cáo hóa học:" Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival | Journal of Translational Medicine BioMed Central Research Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival Loris Bertazza1 2 Simone Mocellin 1 Alberto Marchet1 Pierluigi Pilati1 Joseph Gabrieli1 Romano Scalerta1 and Donato Nitti1 Address Department of Oncological Surgical Sciences Section of Clinica Chirurgica 2 University of Padova via Giustiniani 2 35128 Padua Italy and 2Istituto Oncologico Veneto IRCCS via Gattamelata 64 35128 Padua Italy Email Loris Simone Mocellin - Alberto Marchet-marchet@ Pierluigi Pilati - Joseph Gabrieli - josephgabrieli@ Romano Scalerta - Donato Nitti - Corresponding author Open Access Published 22 December 2009 Received 24 August 2009 . . . _ . . Accepted 22 December 2009 Journal of Translational Medicine 2009 7 111 doi 186 1479-5876-7-111 This article is available from http content 7 1 111 2009 Bertazza et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The detection of circulating tumor cells CTC is considered a promising tool for improving risk stratification in patients with solid tumors. We investigated on whether the expression of CTC related genes adds any prognostic power to the TNM staging system in patients with gastric carcinoma. Methods Seventy patients with TNM stage I to IV gastric carcinoma were retrospectively enrolled. Peripheral blood samples were tested by means of quantitative real time PCR qrtPCR for the expression of four CTC related .