tailieunhanh - báo cáo hóa học:" Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma | Journal of Translational Medicine BioMed Central Research Open Access Correlation between expression of p53 p2l WAFI and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma Mei-Fang Zhang1 2 Zhi-Yi Zhang1 2 Jia Fu1 2 Yu-Feng Yang1 2 and Jing-Ping Yun 1 2 Address 1State Key Laboratory of Oncology in Southern China Cancer Center of Sun Yat-Sen University GuangzhoU China and 2Department of Pathology Cancer Center Sun Yat-Sen University Guangzhou 510060 China Email Mei-Fang Zhang - Zhi-Yi Zhang - ls01zzy@ Jia Fu - fujia81@ Yu- Feng Yang - y313yang@ Jing-Ping Yun - yunjp@ Corresponding author Published 22 December 2009 Received 9 October 2009 _ -T_-mno .nn I lozn rovz 7 I in Accepted 22 December 2009 Journal of Translational Medicine 2009 7 110 doi 186 1479-5876-7-110 This article is available from http content 7 1 110 2009 Zhang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Tumor Protein p53 p53 cyclin-dependent kinase inhibitor 1A p21 WAF1 and murine double minute 2 MDM2 participate in the regulation of cell growth. Altered expression of these gene products has been found in malignant tumors and has been associated with poor prognosis. Our aim was to investigate the expression of the 3 proteins in hepatocellular carcinoma HCC and their prognostic significance. Methods We examined p53 p21 WAF1 and MDM2 expression in 181 pairs of HCC tissues and the adjacent hepatic tissues by performing immunohistochemistry and examined the expression of the 3 proteins in 7 pairs of HCC tissues and the adjacent hepatic tissues by using western blot analysis. Results The expression