tailieunhanh - báo cáo hóa học:" Inflammatory mechanisms in ischemic stroke: therapeutic approaches"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Inflammatory mechanisms in ischemic stroke: therapeutic approaches | Journal of Translational Medicine BioMed Central Review Inflammatory mechanisms in ischemic stroke therapeutic approaches Shaheen E Lakhan Annette Kirchgessner and Magdalena Hofer Open Access Address Global Neuroscience Initiative Foundation Los Angeles CA USA Email Shaheen E Lakhan - slakhan@ Annette Kirchgessner - akirchgessner@ Magdalena Hofer - lhofer@ Corresponding author Published 17 November 2009 Received 3 August 2009 _ _. -mno - .0-7 1107 1Z-7O ro- z 1 0-7 Accepted 17 November 2009 Journal of Translational Medicine 2009 7 97 doi l479-5876-7-97 This article is available from http content 7 1 97 2009 Lakhan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Acute ischemic stroke is the third leading cause of death in industrialized countries and the most frequent cause of permanent disability in adults worldwide. Despite advances in the understanding of the pathophysiology of cerebral ischemia therapeutic options remain limited. Only recombinant tissue-plasminogen activator rt-PA for thrombolysis is currently approved for use in the treatment of this devastating disease. However its use is limited by its short therapeutic window three hours complications derived essentially from the risk of hemorrhage and the potential damage from reperfusion ischemic injury. Two important pathophysiological mechanisms involved during ischemic stroke are oxidative stress and inflammation. Brain tissue is not well equipped with antioxidant defenses so reactive oxygen species and other free radicals oxidants released by inflammatory cells threaten tissue viability in the vicinity of the ischemic core. This review will discuss the molecular aspects of