tailieunhanh - báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Immunological considerations of modern animal models of malignant primary brain tumors | Journal of Translational Medicine BioMed Central Open Access Review Immunological considerations of modern animal models of malignant primary brain tumors Michael E Sughrue Isaac Yang Ari J Kane Martin J Rutkowski Shanna Fang C David James and Andrew T Parsa Address Department of Neurological Surgery University of California at San Francisco San Francisco California USA Email Michael E Sughrue - Mes261@ Isaac Yang - Yangi@ Ari J Kane - Martin J Rutkowski - Shanna Fang - C David James - Andrew T Parsa - Parsaa@ Corresponding author Published 8 October 2009 Received 8 July 2009 Journal of Translational Medicine 2009 7 84 doi 1479-5876-7-84 Accepted 8 October 2009 This article is available from http content 7 1 84 2009 Sughrue et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy including surgery chemotherapy and radiotherapy have prompted numerous investigators to search for new therapeutic approaches to improve quantity and quality of survival from these aggressive lesions. One of these approaches involves triggering a tumor specific immune response. However a difficulty in this approach is the the scarcity of animal models of primary CNS neoplasms which faithfully recapitulate these tumors and their interaction with the host s immune system. In this article we review the existing methods utilized to date for modeling gliomas in rodents with a focus on .