tailieunhanh - báo cáo hóa học:" Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients – a pilot study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients – a pilot study | Journal of Translational Medicine BioMed Central Open Access Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients - a pilot study Sara Bremer1 2 Nils T Vethe1 2 Helge Rootwelt1 Pâl F Jorgensen3 Jean Stenstrom4 Hallvard Holdaas4 Karsten Midtvedt4 and Stein Bergan 1 5 Address Department of Medical Biochemistry Rikshospitalet University Hospital 0027 Oslo Norway institute of Clinical Biochemistry University of Oslo 0027 Oslo Norway 3Section for Transplant Surgery Rikshospitalet University Hospital Oslo 0027 Oslo Norway 4Department of Medicine Rikshospitalet University Hospital 0027 Oslo Norway and 5School of Pharmacy University of Oslo 0316 Oslo Norway Email Sara Bremer - Nils T Vethe - Helge Pâl F Jorgensen - Jean Stenstrom - Hallvard Holdaas - Karsten Midtvedt - Stein Bergan - Corresponding author Published 27 July 2009 Received 11 May 2009 Journal of Translational Medicine 2009 7 64 doi 1479-5876-7-64 Accepted 27 July 2009 This article is available from http content 7 1 64 2009 Bremer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mycophenolic acid MPA is widely used as part of immunosuppressive regimens following allograft transplantation. The large pharmacokinetic PK and pharmacodynamic PD variability and narrow therapeutic range of MPA provide a potential for therapeutic drug monitoring. The objective of this pilot study was to .