tailieunhanh - UPDATE ON MECHANISMS OF HORMONE ACTION – FOCUS ON METABOLISM, GROWTH AND REPRODUCTIONS

Osteoporosis and fractures may increase due to hypoestrogenism in menopause and cytochrome P450 inducing AEDs. Recent studies suggest lower bone mineral density (BMD) in adults and children with epilepsy, irrespective of AED treatment. Both idiopathic epilepsy and symptomatic epilepsy are associated with reduced BMD, with the greatest reduction in symptomatic generalized epilepsy (Sheth & Hermann, 2008). However, the pathophysiological underlying mechanisms are far from understood and likely multifactorial. Potential risk or predisposing factors include physical impairment, genetic factors, AED treatment with enzyme-inducing drugs, AED polytherapy, impact of seizures on the hypothalamus-hypophysis-adrenal (HPA) axis, and vitamin D deficiency/insufficiency. As growth and sexual maturation in adolescence are regulated by a complex. | UPDATE ON MECHANISMS OF HORMONE ACTION - FOCUS ON METABOLISM GROWTH AnD REPRODUCTIONS Edited by Gianluca Aimaretti Co-Editors Paolo Marzullo and Flavia Prodam Update on Mechanisms of Hormone Action - Focus on Metabolism Growth and Reproductions Edited by Gianluca Aimaretti with Paolo Marzullo and Flavia Prodam Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Petra Nenadic Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright 21thDesign 2011. Used under license from First published October 2011 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Update on Mechanisms of Hormone .

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