tailieunhanh - Báo cáo hóa học: " Zinc in innate and adaptive tumor immunity"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Zinc in innate and adaptive tumor immunity | John et al. Journal of Translational Medicine 2010 8 118 http content 8 1 118 JOURNAL OF TRANSLATIONAL MEDICINE REVIEW Open Access Zinc in innate and adaptive tumor immunity Erica John1 Thomas C Laskow1 William J Buchser1 Bruce R Pitt2 Per H Basse3 Lisa H Butterfield4 Pawel Kalinski1 Michael T Lotze1 Abstract Zinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element critical for cell growth development and differentiation DNA synthesis RNA transcription cell division and cell activation. Zinc deficiency has adverse consequences during embryogenesis and early childhood development particularly on immune functioning. It is essential in members of all enzyme classes including over 300 signaling molecules and transcription factors. Free zinc in immune and tumor cells is regulated by 14 distinct zinc importers ZIP and transporters ZNT1-8 . Zinc depletion induces cell death via apoptosis or necrosis if apoptotic pathways are blocked while sufficient zinc levels allows maintenance of autophagy. Cancer cells have upregulated zinc importers and frequently increased zinc levels which allow them to survive. Based on this novel synthesis approaches which locally regulate zinc levels to promote survival of immune cells and or induce tumor apoptosis are in order. Finding a potent role for zinc in the regulation of autophagic PCD establishes zinc deprivation as a universal cell death signal regardless of which route of degrada-tion-apoptotic or autophagic -is chosen by cells. Andreas Helmersson Sara von Arnold and Peter V. Bozhkov. The Level of Free Intracellular Zinc Mediates Programmed Cell Death Cell Survival Decisions in Plant Embryos. Plant Physiol. 2008 July 147 3 1158-1167. It s a business. If I could make more money down in the zinc mines I d be mining zinc. Roger Maris American professional Baseball Player. 1934-1985 We have everything but the kits in zinc. Albert Donnenberg PhD