tailieunhanh - EDUCATION IN HEART - Volume 1

The inflammatory process both reduces collagen synthesis by inhibiting the smooth muscle cell and causes its death by apoptosis. Macrophages also produce a wide range of metalloproteinases capable of degrading all the components of the connective tissue matrix, including collagen. These metalloproteinases are secreted into the tissues in an inactive form and then activated by plasmin. Metalloproteinase production by macrophages is upregulated by inflammatory cytokines such as TNFá. Plaque disruption is therefore now seen as an auto-destruct phenomenon associated with an enhanced inflammatory activation | EDUCATION IN HEART Volume 1 Series Editor PETER MILLS Consultant Cardiologist London Chest Hospital BMI Books BMJ Books 2001 BMJ Books is an imprint of the BMJ Publishing Group All rights reserved. No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means electronic mechanical photocopying recording and or otherwise without the prior written permission of the publishers First published in 2001 by BMJ Books BMA House Tavistock Square London WC1H 9JR British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library ISBN 0-7279-1620-3 Cover design by Marritt Associates Harrow Middlesex Typeset by BMJ Electronic Production and Scribe Design Gillingham Kent Printed in Malaysia by Times .

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