tailieunhanh - Báo cáo hóa học: "Evaluation of six CTLA-4 polymorphisms in highrisk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trial"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Evaluation of six CTLA-4 polymorphisms in highrisk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trial | Gogas et al. Journal of Translational Medicine 2010 8 108 http content 8 1 108 RESEARCH JOURNAL OF TRANSLATIONAL MEDICINE Open Access Evaluation of six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon therapy in the He13A 98 multicenter trial I loloro r r tnTỉc 1l r l2 ÍT ii2 IZmmn3 Qnưrnin ni ilr ti i- l2f hr j I4 v nnic i ioi 2V2c1 R ir-HHiroHor5 Helen Gogds Uidnid Udini Heniy Koon Ividiid Spyiopoulou Vlddiou Idnnis Metdxds Elizdbeth Buchbindei Eirini Pectdsides1 Dimosthenis Tsoutsos6 Aiistidis Polyzos1 Alexdndios Stidtigos7 Chiistos Mdikopoulos1 Doirr ic D n3 1 iI6 Cqomo Pmi it i f 7ÌlTỉc8 Hl r TỉctTỉroTỉ9 D nfolic Cl Qt lr ic10 í lir H2qI R Atlziroc5 Petios Pdndgiotou Geoige Fountzilds Ouidnid Cdstdnd Pdntelis Skdilos Michdel D Atkins John M Kiikwood11 ABSTRACT Purpose Interferon is dppioved foi ddjuvdnt tiedtment of pdtients with stdge IIb III meldnomd. The toxicity dnd unceitdinty iegdiding suivivdl benefits of interferon hdve qudlified its dcceptdnce despite significdnt durable ieldpse pievention in d fraction of pdtients. Piedictive biomdikeis thdt would endble selection of pdtients foi therapy would hdve d ldige impdct upon clinicdl practice. Specific CTLA-4 polymoiphisms hdve previously shown dn dssocidtion with response to CTLA-4 blockdde in pdtients with metdstdtic meldnomd dnd the development of dutoimmunity. Experimental design 286 meldnomd pdtients dnd 288 hedlthy controls weie genotyped foi six CTLA-4 polymoiphisms previously suggested to be impoitdnt AG 49 CT 318 CT 60 JO 27 JO30 dnd JO 31 . Specific dllele frequencies weie compdied between the hedlthy dnd pdtient populdtions ds well ds presence oi dbsence of these in ieldtion to iecuiience. Alleles ieldted to dutoimmune disedse weie dlso investigdted. Results No significdnt differences weie found between the distributions of CTLA-4 polymoiphisms in the meldnomd populdtion compdied with hedlthy controls. Reldpse fiee suivivdl RFS dnd .

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