tailieunhanh - Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance | Peng et al. Journal of Translational Medicine 2010 8 101 http content 8 1 101 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion laboratory evidence and clinical significance Chun-Wei Peng Xiu-Li Liu Xiong Liu Yan Li Abstract Background Cancer invasion results from constant interactions between cancer cells and their microenvironment. Major components of the cancer microenvironment are stromal cells infiltrating inflammatory cells collagens matrix metalloproteinases MMP and newly formed blood vessels. This study was to determine the roles of MMP-9 MMP-2 type IV collagen infiltrating macrophages and tumor microvessels in gastric cancer GC invasion and their clinico-pathological significance. Methods Paraffin-embedded tissue sections from 37 GC patients were studied by Streptavidin-Peroxidase SP immunohistochemical technique to determine the levels of MMP-2 MMP-9 type IV collagen macrophages infiltration and microvessel density MVD . Different invasion patterns were delineated and their correlation with major clinico-pathological information was explored. Results MMP2 expression was higher in malignant gland compared to normal gland especially nearby the basement membrane BM . High densities of macrophages at the interface of cancer nests and stroma were found where BM integrity was destroyed. MMP2 expression was significantly increased in cases with recurrence and distant metastasis P and respectively . Infiltrating macrophages were correlated with serosa invasion P and TNM stage P . MVD was higher in type IV collagen negative group compared to type IV collagen positive group P . MVD was related to infiltrating macrophages density P . Patients with negative MMP9 expression had better overall survival OS compared to those with positive MMP9 expression Median OS vs mo P . Median OS was .