tailieunhanh - Báo cáo hóa học: " Increased shedding of HU177 correlates with worse prognosis in primary melanoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Increased shedding of HU177 correlates with worse prognosis in primary melanoma | Hamilton et al. Journal of Translational Medicine 2010 8 19 http content 8 1 19 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Increased shedding of HU177 correlates with worse prognosis in primary melanoma 11 11 2 3 3 2 Heather K Hamilton Amy E Rose Paul J Christos Richard L Shapiro Russell S Berman Madhu Mazumdar Michelle W Ma1 Daniel Krich1 Leonard Liebes4 Peter C Brooks5 6 Iman Osman1 Abstract Background Increased levels of cryptic collagen epitope HU177 in the sera of melanoma patients have been shown to be associated with thicker primary melanomas and with the nodular histologic subtype. In this study we investigate the association between HU177 shedding in the sera and clinical outcome in terms of disease-free survival DFS and overall survival OS . Methods Serum samples from 209 patients with primary melanoma prospectively enrolled in the Interdisciplinary Melanoma Cooperative Group at the New York University Langone Medical Center mean age 58 mean thickness mm stage I 136 stage II 41 stage III 32 median follow-up months were analyzed for HU177 concentration using a validated ELISA assay. HU177 serum levels at the time of diagnosis were used to divide the study cohort into two groups low and high HU177. DFS and OS were estimated by Kaplan-Meier survival analysis and the log-rank test was used to compare DFS and OS between the two HU177 groups. Multivariate Cox proportional hazards regression models were employed to examine the independent effect of HU177 category on DFS and OS. Results HU177 sera concentrations ranged from ng ml mean and median of ng ml and ng ml respectively . Thirty-eight of the 209 18 patients developed recurrences and 34 of the 209 16 patients died during follow-up. Higher HU177 serum level was associated with an increased rate of melanoma recurrence p and with increasing mortality p . The association with overall survival remained statistically significant after