tailieunhanh - Báo cáo hóa học: " Immune and hemorheological changes in Chronic Fatigue Syndrome"

Immune and hemorheological changes in Chronic Fatigue Syndrome | Brenu et al. Journal of Translational Medicine 2010 8 1 http content 8 1 1 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Immune and hemorheological changes in Chronic Fatigue Syndrome Pl I A 1 1 2 A Z X I I D C - ik-XT-Xf 1 3 A I I 7 s o X r 1 1 I e t 4 fl I Ar L Fz-X U .2 c r . I r D D X wx r 2 Dh rr K l Lx VI r F 2 EKua W Brenu Donald R Staines oguz K BasKurt Kevin J Ashton Sandra B Ramos Rhys M Christy Sonya M Marshall-GraaisniK1 2 Abstract Background Chronic Fatigue Syndrome CFS is a multifactorial disorder that affects various physiological systems including immune and neurological systems. The immune system has been substantially examined in CFS with equivocal results however little is Known about the role of neutrophils and natural Killer NK phenotypes in the pathomechanism of this disorder. Additionally the role of erythrocyte rheological characteristics in CFS has not been fully expounded. The objective of this present study was to determine deficiencies in lymphocyte function and erythrocyte rheology in CFS patients. Methods Flow cytometric measurements were performed for neutrophil function lymphocyte numbers NK phenotypes CD56dimCD16 and CD56brightCD16- and NK cytotoxic activity. Erythrocyte aggregation deformability and fibrinogen levels were also assessed. Results CFS patients n 10 had significant decreases in neutrophil respiratory burst NK cytotoxic activity and CD56brightCD16- NK phenotypes in comparison to healthy controls n 10 . However hemorheological characteristic aggregation deformability fibrinogen lymphocyte numbers and CD56dimCD16 NK cells were similar between the two groups. Conclusion These results indicate immune dysfunction as potential contributors to the mechanism of CFS as indicated by decreases in neutrophil respiratory burst NK cell activity and NK phenotypes. Thus immune cell function and phenotypes may be important diagnostic marKers for CFS. The absence of rheological changes may indicate