tailieunhanh - báo cáo hóa học:" Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life | Journal of Translational Medicine BioMed Central Open Access Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life Hemant Sarin 1 2 Ariel S Kanevsky2 Steve H Fung3 John A Butman2 Robert W Cox4 Daniel Glen4 Richard Reynolds4 and Sungyoung Auh5 Address National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda Maryland 20892 USA 2Radiology and Imaging Sciences Program Clinical Center National Institutes of Health Bethesda Maryland 20892 USA 3Neuroradiology Department Massachusetts General Hospital Boston Massachusetts 02114 USA 4Scientific and Statistical Computing Core National Institute of Mental Health Bethesda Maryland 20892 USA and 5Biostatistics National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland 20892 USA Email Hemant Sarin - sarinh@ Ariel S Kanevsky-kanevskya@ Steve H Fung-SFUNG@ John A Butman - JButmanA@ Robert W Cox - robertcox@ Daniel Glen - glend@ Richard Reynolds - reynoldr@ Sungyoung Auh - auhs@ Corresponding author Published 13 May 2009 Received 25 March 2009 Journal of Translational Medicine 2009 7 33 doi l479-5876-7-33 Accepted 13 May 2009 This article is available from http content 7 1 33 2009 Sarin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The intravenous co-infusion of labradimil a metabolically stable bradykinin B2 receptor agonist has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs such as carboplatin across the .