tailieunhanh - báo cáo hóa học:" Highly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Highly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation | Journal of Translational Medicine BioMed Central Open Access Highly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation Philippe Veron1 2 Sylvie Boutin1 Samia Martin1 Laurence Chaperot3 Joel Plumas3 Jean Davoust1 4 and Carole Masurier 1 Address 1Laboratoire d lmmunologie GENETHON CNRS UMR 8115 91002 EVRY Cedex France 2GENOSAFE SA 91002 EVRY Cedex France 3Service EFS Rhône-Alpes La Tronche F-38701 Inserm U823 Immunobiologie et Immunothérapie des cancers La Tronche F-38706 Univ Joseph Fourier Grenoble F-38041 France and 4INSERM U580 Hôpital Necker-Enfants-Malades Université Paris Descartes Faculté de Médecine René Descartes 75015 Paris France Email Philippe Veron - veron@ Sylvie Boutin - boutin@ Samia Martin - martin@ Laurence Chaperot - Joel Plumas - Jean Davoust - Carole Masurier - masurier@ Corresponding author Published 27 January 2009 Received 5 September 2008 Journal of Translational Medicine 2009 7 10 doi 1479-5876-7-10 Accepted 27 January 2009 This article is available from http content 7 1 10 2009 Veron et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gene modified dendritic cells DC are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. Among the different DC subsets plasmacytoid DC pDC are well known for their ability to recognize and respond to a variety of viruses by secreting high levels of type I interferon. Methods We analyzed here the transduction efficiency of a pDC cell line and of pDC derived from CD34 .