tailieunhanh - báo cáo hóa học:" "Sequencing-grade" screening for BRCA1 variants by oligo-arrays"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :"Sequencing-grade" screening for BRCA1 variants by oligo-arrays | Journal of Translational Medicine BioMed Central Open Access Sequencing-grade screening for BRCAI variants by oligo-arrays Alessandro Monaco1 4 Filippo Menolascina2 4 Yingdong Zhao3 Stefania Tommasi4 Marianna Sabatino1 Ross Fasano1 Angelo Paradiso4 Francesco M Marincola1 and Ena Wang 1 Address DepartmentofTransfusion Medicine Clinical Center National Institutes of Health Bethesda MD USA 2Department of Bioinformatics University of Bari Italy 3Biometrics Research Branch National Cancer Institute National Institutes of Health Bethesda MD Italy and 4Clinical Experimental Oncology Laboratory Istituto Tumori IRCCS Giovanni Paolo II Bari Italy Email Alessandro Monaco - monacoal@ Filippo Menolascina - YingdongZhao - Zhaoy@ Stefania Tommasi - Marianna Sabatino - sabatinom@ Ross Fasano - fasanor@ Angelo Paradiso - Francesco M Marincola - fmarincola@ Ena Wang - ewang@ Corresponding author Published 30 October 2008 Received 15 August 2008 r-T- . . J. . . A J _. inAit A Accepted 30 October 2008 Journal of Translational Medicine 2008 6 64 doi l479-5876-6-64 This article is available from http content 6 1 64 2008 Monaco et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ The need for fast efficient and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for gene-specific single nucleotide polymorphism SNP genotyping. This cost-effective high-throughput strategy has high sensitivity