tailieunhanh - báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :More insights into the immunosuppressive potential of tumor exosomes | Journal of Translational Medicine BioMed Central Open Access Editorial More insights into the immunosuppressive potential of tumor exosomes Veronica Huber1 Paola Filipazzi1 Manuela lero1 Stefano Fais2 and Licia Rivoltini 1 Address 1Unit of Immunotherapy of Human Tumors Fondazione IRCCS Istituto Nazionale Tumori Milan Italy and 2Department of Drug Research and Evaluation Anti-Tumor Drugs Section Istituto Superiore di Sanità Rome Italy Email Veronica Huber - Paola Filipazzi - Manuela Iero - Stefano Fais - Licia Rivoltini - Corresponding author Published 30 October 2008 Received 24 October 2008 rm Accepted 30 October 2008 Journal of Translational Medicine 2008 6 63 doi 1479-5876-6-63 This article is available from http content 6 1 63 2008 Huber et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. We did read with great interest the recent review published by Ichim et al on the potential role of tumor exosomes as immune escape mechanism 1 and we were pleased to see that the authors shared our original idea that these organelles may represent a crucial tool of immunosuppression in cancer 2 3 . Indeed although tumor cells are well acknowledged to affect immune functions through the release of diverse soluble factors or cell-to-cell contact mediated mechanisms 4 5 the involvement of alternative pathways based on the secretion of membrane microvesicles has been so far largely unappreciated 6 . Exosomes are endosome-derived organelles of 50-100 nm size actively secreted by virtually all cell types through an exocytosis pathway