tailieunhanh - báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer | Journal of Translational Medicine BioMed Central Open Access Serum high mobility group box-1 HMGBI is closely associated with the clinical and pathologic features of gastric cancer Hye Won Chung1 Sang-Guk Lee2 Heejung Kim2 Duck Jin Hong2 Jae Bock Chung1 David Stroncek3 and Jong-Baeck Lim 2 Address Department of Internal Medicine Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea 2Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea and 3Department of Transfusion Medicine Warren G Magnuson Clinical Center National Institutes of Health Bethesda Maryland USA Email Hye Won Chung - hwchungmd@ Sang-Guk Lee - COMFORTER6@ Heejung Kim - hjkim12@ Duck Jin Hong - dududuckt@ Jae Bock Chung - jbchung@ David Stroncek - Dstroncek@ Jong-Baeck Lim - jlim@ Corresponding author Published 28 May 2009 Received 16 February 2009 Journal of Translational Medicine 2009 7 38 doi l479-5876-7-38 Accepted 28 May 2009 This article is available from http content 7 1 38 2009 Chung et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background High mobility group box- 1 HMGB1 is a newly recognized factor regulating cancer cell tumorigenesis expansion and invasion. We investigated the correlation between the serum HMGB1 levels and the clinical and pathologic features of gastric cancer and evaluated the validity of HMGB1 as a potential biomarker for the early diagnosis of gastric cancer. Methods A total of 227 subjects were classified into 5 disease groups .