tailieunhanh - Báo cáo y học: "Gene function and expression level influence the insertion/fixation dynamics of distinct transposon families in mammalian introns"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Gene function and expression level influence the insertion/fixation dynamics of distinct transposon families in mammalian introns. | Open Access Research Gene function and expression level influence the insertion fixation dynamics of distinct transposon families in mammalian introns Manuela Sironi Giorgia Menozzi Giacomo P Comp Matteo Cereda Rachele Cagliani Nereo Bresolin and Uberto Pozzoli Addresses Scientific Institute IRCCS E Medea Bioinformatic Lab Via don L Monza 23842 Bosisio Parini LC Italy. tDino Ferrari Centre Department of Neurological Sciences University of Milan IRCCS Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation 20100 Milan Italy. Correspondence Uberto Pozzoli. Email Published 20 December 2006 Genome Biology 2006 7 RI20 doi gb-2006-7- 12-r 120 The electronic version of this article is the complete one and can be found online at http 2006 7 12 R120 Received 31 July 2006 Revised 25 October 2006 Accepted 20 December 2006 2006 Sironi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Transposable elements TEs represent more than 45 of the human and mouse genomes. Both parasitic and mutualistic features have been shown to apply to the host-TE relationship but a comprehensive scenario of the forces driving TE fixation within mammalian genes is still missing. Results We show that intronic multispecies conserved sequences MCSs have been affecting TE integration frequency over time. We verify that a selective economizing pressure has been acting on TEs to decrease their frequency in highly expressed genes. After correcting for GC content MCS density and intron size we identified TE-enriched and TE-depleted gene categories. In addition to developmental regulators and transcription factors TE-depleted regions encompass loci that might require subtle .