tailieunhanh - Báo cáo y học: "Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. | Open Access Research Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome Casey M Bergman Hadi Quesneville Dominique Anxolabéhère and Michael Ashburner Addresses Department of Genetics University of Cambridge Cambridge CB2 3EH UK. Taculty of Life Sciences University of Manchester Manchester M13 9PT UK. Laboratoire de Bioinformatique et Génomique Institut Jacques Monod place Jussieu 75251 Paris cedex 05 France. Laboratoire Dynamique du Génome et Evolution Institut Jacques Monod place Jussieu 75251 Paris cedex 05 France. Correspondence Casey M Bergman. Email Published 29 November 2006 Genome Biology 2006 7 R112 doi gb-2006-7- 11-r112 The electronic version of this article is the complete one and can be found online at http 2006 7 11 R1 12 Received 31 July 2006 Revised 13 November 2006 Accepted 29 November 2006 2006 Bergman et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The recent availability of genome sequences has provided unparalleled insights into the broad-scale patterns of transposable element TE sequences in eukaryotic genomes. Nevertheless the difficulties that TEs pose for genome assembly and annotation have prevented detailed quantitative inferences about the contribution of TEs to genomes sequences. Results Using a high-resolution annotation of TEs in Release 4 genome sequence we revise estimates of TE abundance in Drosophila melanogaster. We show that TEs are non-randomly distributed within regions of high and low TE abundance and that pericentromeric regions with high TE abundance are mosaics of distinct regions of extreme and normal TE density. Comparative