tailieunhanh - Báo cáo y học: "Genomic features of Bordetella parapertussis clades with distinct host species specificity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genomic features of Bordetella parapertussis clades with distinct host species specificity. | Research Open Access Genomic features of Bordetella parapertussis clades with distinct host species specificity Mary M Brinig Karen B Register Mark R Ackermann and David A Relman Addresses Department of Microbiology and Immunology Stanford University School of Medicine Stanford California 94305 USA. VA Palo Alto Health Care System Palo Alto California 94304 USA. USDA ARS National Animal Disease Center Respiratory Diseases of Livestock Research Unit Ames Iowa 50010 USA. Department of Veterinary Pathology Iowa State University Ames Iowa 50011 USA. Department of Medicine Stanford University School of Medicine Stanford California 94305 USA. Correspondence Mary M Brinig. Email mbrinig@ Published 6 September 2006 Genome Biology 2006 7 R8I doi I86 gb-2006-7-9-r8I The electronic version of this article is the complete one and can be found online at http 2006 7 9 R8I Received 10 May 2006 Revised 14 July 2006 Accepted 6 September 2006 2006 Brinig et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The respiratory pathogen Bordetella parapertussis is a valuable model in which to study the complex phenotype of host specificity because of its unique two-species host range. One subset of strains including the sequenced representative causes whooping cough in humans while other strains infect only sheep. The disease process in sheep is not well understood nor are the genetic and transcriptional differences that might provide the basis for host specificity among ovine and human strains. Results We found 40 previously unknown genomic regions in an ovine strain of B. parapertussis using subtractive hybridization including unique lipopolysaccharide genes. A microarray survey of the .