tailieunhanh - Báo cáo y học: "Phagosome proteomes open the way to a better understanding of phagosome function"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Phagosome proteomes open the way to a better understanding of phagosome function. | Minireview Phagosome proteomes open the way to a better understanding of phagosome function Gareth Griffiths and Luis Mayorga Addresses Cell Biology Program EMBL Meyerhofstrasse 69117 Heidelberg Germany. IHEM . Cuyo-CONICET Casilla de Correo Mendoza 5500 Argentina. Correspondence Gareth Griffiths. Email Published 15 March 2007 Genome Biology 2007 8 207 doi gb-2007-8-3-207 The electronic version of this article is the complete one and can be found online at http 2007 8 3 207 2007 BioMed Central Ltd Abstract Phagocytic cells take up microbes and other particles into membrane-bounded organelles called phagosomes. Studies on the protein and lipid composition of model phagosomes containing latex beads are the first step in a systems-biology approach to understanding how these organelles function. Early in their evolution eukaryotic cells acquired the capacity to take up microbes by phagocytosis as a source of food. Since then phagocytosis has evolved into a highly complex and regulated process and is one of the main ways in which multicellular animals clear the body of pathogenic microbes and cellular debris. Microbes and other particles are taken up by phagocytosis into an intracellular membrane-bounded organelle called a phagosome Figure 1 . This eventually fuses with other organelles notably endosomes and lysosomes resulting in a gradual alteration of the composition and function of the phagosome a process referred to as phagosome maturation. After full maturation the phagosome will contain a battery of hydrolytic enzymes and have an internal pH as low as Figure 1 . In the vast majority of cases the microbe inside the phagosome is killed and digested but a number of important pathogens including the bacterium Mycobacterium tuberculosis which kills around two million people each year have acquired the ability to survive and even replicate in this hostile environment. Each type of pathogen that .