tailieunhanh - Báo cáo y học: "microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. | Research Open Access microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder Diana O Perkins Clark D Jeffries L Fredrik Jarskog J Michael Thomson Keith Woods Martin A Newman Joel S Parker Jianping Jin and Scott M Hammond Addresses Department of Psychiatry University of North Carolina at Chapel Hill CB 7160 Chapel Hill NC 27599 USA. School of Pharmacy University of North Carolina at Chapel Hill CB 7360 Chapel Hill NC 27599 USA. Renaissance Computing Institute University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA. Department of Cell and Developmental Biology University of North Carolina at Chapel Hill CB 7090 Chapel Hill NC 27599 USA. Constella Group LLC Meridian Parkway Durham NC 27713 USA. Department of Molecular Biology University of North Carolina at Chapel Hill CB 7104 Chapel Hill NC 27599 USA. Correspondence Clark D Jeffries. Email clark_jeffries@ Published 27 February 2007 Genome Biology 2007 8 R27 doi 186 gb-2007-8-2-r27 The electronic version of this article is the complete one and can be found online at http 2007 8 2 R27 Received 24 November 2006 Revised 25 January 2007 Accepted 27 February 2007 2007 Perkins et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background microRNAs miRNAs are small noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases including Tourette s syndrome Fragile X syndrome and several types of cancer. Results We hypothesized that schizophrenia might be associated with altered miRNA profiles. To investigate this possibility we compared the expression of 264 human miRNAs from