tailieunhanh - Báo cáo y học: "A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population. | Open Access Research A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population Valeria Mattiangeli Anthony W Ryan Ross McManus and Daniel G Bradley Addresses Smurfit Institute of Genetics Trinity College Dublin 2 Ireland. Department of Clinical Medicine Trinity Centre for Health Science Institute of Molecular Medicine Dublin Molecular Medicine Centre St James s Hospital Dublin Ireland. Trinity College Dublin Ireland. Correspondence Daniel G Bradley. Email dbradley@ Published II August 2006 Genome Biology 2006 7 R74 doi I86 gb-2006-7-8-r74 The electronic version of this article is the complete one and can be found online at http 2006 7 8 R74 Received I4 February 2006 Revised 26 May 2006 Accepted I I August 2006 2006 Mattiangeli et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In this study we present a single population test Ewens-Waterson applied in a genomic context to investigate the presence of recent positive selection in the Irish population. The Irish population is an interesting focus for the investigation of recent selection since several lines of evidence suggest that it may have a relatively undisturbed genetic heritage. Results We first identified outlier single nucleotide polymorphisms SNPs from previously published genome-wide data with high FST branch specification in a European-American population. Eight of these were chosen for further analysis. Evidence for selective history was assessed using the Ewens-Watterson s statistic calculated using Irish genotypes of microsatellites flanking the eight outlier SNPs. Evidence suggestive of selection was detected in three of these by comparison with a .