tailieunhanh - Báo cáo y học: "The future is genome-wide"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The future is genome-wide. | Meeting report The future is genome-wide Samuel Deutsch and Alexandre Reymond Addresses Department of Genetic Medicine and Development University of Geneva Medical School Geneva CH-1211 Switzerland. fCenter for Integrative Genomics University of Lausanne Lausanne CH-1015 Switzerland. Correspondence Alexandre Reymond. Email Published 24 August 2006 Genome Biology 2006 7 324 doi gb-2006-7-8-324 The electronic version of this article is the complete one and can be found online at http 2006 7 8 324 2006 BioMed Central Ltd A report of the annual meeting of the European Society of Human Genetics Amsterdam 6-9 May 2006. More than 1 700 human geneticists from 59 countries congregated in Amsterdam in May for this year s meeting of the European Society of Human Genetics which mainly focused on the use of post-genome analysis tools to dissect the causes of and mechanisms governing complex traits. Many of the exciting studies presented were based on two technologies array-based methods for genome-wide genotyping or technologies for high-density comparative genome hybridization CGH . A highlight of the meeting was the keynote lecture by Nobel laureate Sydney Brenner Salk Institute for Biological Studies La Jolla USA on humanity s genes which focused on the challenges we face in transforming the information from the human genome into concrete benefits for our societies. Whole-genome association studies of complex phenotypes This year has seen the success of several whole-genome association studies using genotyping for single-nucleotide polymorphisms SNPs to identify genes responsible for some common complex phenotypes for both discrete and quantitative traits. A plenary lecture by Kari Stefansson deCODE Genetics Reykjavik Iceland highlighted the tremendous potential of this approach. Several examples were discussed in which new genes have recently been identified using a combination of linkage and association analysis .