tailieunhanh - Báo cáo y học: " Signaling netwErks get the global treatment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Signaling netwErks get the global treatment. | Minireview Signaling netwErks get the global treatment Michael B Yaffe and Forest M White Addresses Center for Cancer Research Department of Biology and Biological Engineering Division Massachusetts Institute of Technology Cambridge MA 02139 USA. Correspondence Michael B Yaffe. Email myaffe@ Published I February 2007 Genome Biology 2007 8 202 doi gb-2007-8-I-202 The electronic version of this article is the complete one and can be found online at http 2007 8 I 202 2007 BioMed Central Ltd Abstract Two landmark studies of cell signaling by RNA interference and phosphoproteomics provide complementary global views of the pathways downstream of receptor kinases including those regulated by Erks. In the prelapsarian days of signal transduction pathways were simple everything was linear and life was good. Like the misfortunes that befell Voltaire s Candide however the unfortunate intervention of reality has clouded that wonderfully innocent view by adding layer upon layer of complexity to what was once neat clean and relatively easy to think about. Consider the signaling pathways that regulate protein phosphorylation the most common post-translational modification of proteins. These pathways and networks regulate almost all aspects of cell biology and when dysregulated have been implicated in the pathology of a wide range of human disorders ranging from cancer to neurodegeneration. To understand how information flows through these networks and to identify critical nodes within protein-kinase signaling pathways that should be targeted for therapeutic intervention it becomes necessary to understand the molecular mechanisms that underlie network regulation in all their gory detail. This presents us with two fundamental challenges first all of the components that touch the network need to be identified along with their dynamic regulatory points second the physical and functional connections within the network must be mapped. Until now both .