tailieunhanh - Báo cáo y học: "Unraveling the transcriptional network controlling ES cell pluripotency"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Unraveling the transcriptional network controlling ES cell pluripotency. | Minireview Unraveling the transcriptional network controlling ES cell pluripotency Sridhar Rao and Stuart H Orkin Addresses Division of Hematology-Oncology Children s Hospital and the Dana Farber Cancer Institute Harvard Medical School Boston MA 02115 USA. fHarvard Stem Cell Institute and the Howard Hughes Medical Institute 1 Blackfan Circle Karp Research Building Children s Hospital Boston MA 02115 USA. Correspondence Stuart H Orkin. Email stuart_orkin@ Published 30 August 2006 Genome Biology 2006 7 230 doi gb-2006-7-8-230 The electronic version of this article is the complete one and can be found online at http 2006 7 8 230 2006 BioMed Central Ltd Abstract Embryonic stem cells ES cells are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate transcriptional pathways in ES cells for maintenance of the undifferentiated state and for self-renewal. Embryonic stem cells ES cells are derived from the inner cell mass ICM of the early mammalian embryo and are distinguished by two remarkable properties. First they can be propagated in tissue culture in an undifferentiated state for an extended period that is they have the property of selfrenewal. Second when introduced into a host blastocyst they contribute to all tissues and even the germ cells of the resulting chimeric animal they have the property of pluripotency. These features have been exploited in studies of early development and for the generation of genetically engineered mice 1 . Recently the pluripotency and self-renewal of ES cells have come under close scrutiny. An important goal is an understanding of the unique pathways used by these cells with the intent of recreating them in somatic cells and thereby reprogramming differentiated cells to an embryonic-like state. In a recent set of experiments Ivanova et al. 2 set out to uncover these .