tailieunhanh - Báo cáo y học: "Genome re-annotation: a wiki solution"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genome re-annotation: a wiki solution? | Opinion Genome re-annotation a wiki solution Steven L Salzberg Address Center for Bioinformatics and Computational Biology and Department of Computer Science 3125 Biomolecular Sciences Building University of Maryland College Park MD 20742 USA. Email salzberg@ Published I February 2007 Genome Biology 2007 8 I02 doi gb-2007-8-I-I02 The electronic version of this article is the complete one and can be found online at http 2007 8 I I02 2007 BioMed Central Ltd Abstract The annotation of most genomes becomes outdated over time owing in part to our ever-improving knowledge of genomes and in part to improvements in bioinformatics software. Unfortunately annotation is rarely if ever updated and resources to support routine reannotation are scarce. Wiki software which would allow many scientists to edit each genome s annotation offers one possible solution. So you think that gene you just retrieved from GenBank 1 is correct Are you certain If it is a eukaryotic gene and especially if it is from an unfinished genome there is a pretty good chance that the amino acid sequence is wrong. And depending on when the genome was sequenced and annotated there is a chance that the description of its function is wrong too. Large-scale genome sequencing has revolutionized biology over the past ten years generating vast amounts of new information that has radically transformed our understanding of hundreds of species including ourselves. Sequencing centers continue to churn out new DNA sequences for a fantastic variety of species covering more and more of the tree of life. Along with these sequences the centers also produce genome annotation which includes the locations and descriptions of all identifiable genes. These gene lists are the first pictures we get of what s inside a newly sequenced genome and they can reveal key insights into what makes an organism distinctive. Sometimes the gene lists themselves are part of the story for example when the