tailieunhanh - Báo cáo y học: "Regulatory RNAs and the demise of ‘junk’ DNA"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Regulatory RNAs and the demise of ‘junk’ DNA. | Meeting report Regulatory RNAs and the demise of junk DNA Frank J Slack Address Department of Molecular Cellular and Developmental Biology Yale University New Haven CT 06520 USA. Email Published 28 September 2006 Genome Biology 2006 7 328 doi gb-2006-7-9-328 The electronic version of this article is the complete one and can be found online at http 2006 7 9 328 2006 BioMed Central Ltd A report of the meeting Regulatory RNAs the 71st Cold Spring Harbor Symposium on Quantitative Biology Cold Spring Harbor USA 31 May-5 July 2006. A growing body of work suggests that genes for noncoding RNAs make up a substantial class of genes in all organisms with increasing organismal complexity correlated with an increasing complexity of noncoding RNAs. Many of these noncoding RNAs appear to have regulatory functions and these were the subject of this year s annual Cold Spring Harbor Symposium. Among the most exciting themes of the meeting were the evidence for significant amounts of hitherto undiscovered transcription in genomes and the discovery of novel classes of noncoding RNAs with thousands of members. In this report I review a few of these highlights. The tenets of the central dogma have required revision over the past few decades as biologists have begun to appreciate that RNA performs many functions once thought solely to be the domain of proteins. Apart from its well established roles as messenger ribosomal component and transfer RNA it is now clear that RNA can have a key role in regulating gene expression. Noncoding regulatory RNAs - RNAs that are not translated into protein - include the small nuclear RNAs snRNAs the small nucleolar RNAs snoRNAs the XIST RNA that mediates mammalian X-chromosome silencing microRNAs riboswitches and the RNA component of the enzyme telomerase. These RNAs direct such diverse processes as gene silencing transcriptional and translational control imprinting and dosage compensation. These .