tailieunhanh - Báo cáo sinh học: "Bunched and Madm: a novel growth-regulatory complex"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Bunched and Madm: a novel growth-regulatory complex? | Harvey Journal of Biology 2010 9 8 http content 9 1 8 Journal of Biology MINIREVIEW L__ Bunched and Madm a novel growth-regulatory complex Kieran F Harvey See research article at http content 9 1 9 Abstract By combining Drosophila genetics and proteomics Gluderer et al. report in this issue of Journal of Biology the isolation of a novel growth-regulatory complex consisting of Bunched and Madm. Future study of this complex will address the precise mechanism of growth control regulation of complex activity the interface with other growth pathways and a potential role in human cancer. Cancer is a complex group of diseases that stems from the accumulation of mutations in genes that control fundamental biological processes such as cell growth proliferation survival and migration. The study of model organisms has provided several seminal contributions to our understanding of cancer originating with Theodor Boveri s hypothesis drawn from sea urchin-based studies in the early 1900s that cancer arises because of chromosomal abnormalities 1 . In more recent times mutations in dozens of genes have been shown to contribute to the genesis of different cancers and their discovery has been facilitated by various approaches isolation of oncogenic viruses close examination of familial cancer cytogenetics positional cloning genetic screens in model organisms followed by analysis of mutation status of human homologs in cancerous cells genome-wide analysis of gene expression and copy number changes and high-throughput sequencing and genome-wide association studies. Flies and cancer Drosophila melanogaster has proved to be a very valuable organism for the discovery of novel signaling proteins Correspondence Cell Growth and Proliferation Laboratory Peter MacCallum Cancer Centre 7 St Andrews Place East Melbourne Victoria 3002 Australia and Department of Pathology University of Melbourne Parkville Victoria 3010 Australia 2 BioMed .