tailieunhanh - Báo cáo sinh học: "Regulation of metabolism in Caenorhabditis elegans longevity"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Regulation of metabolism in Caenorhabditis elegans longevity. | Gallo and Riddle Journal of Biology 2010 9 7 http content 9 1 7 Journal of Biology MINIREVIEW L__ Regulation of metabolism in Caenorhabditis elegans longevity Marco Gallo1 and Donald L Riddle 1 2 See research article http 1741-7007 8 14 Abstract The nematode Caenorhabditis elegans is a favorite model for the study of aging. A wealth of genetic and genomic studies show that metabolic regulation is a hallmark of life-span modulation. A recent study in BMC Biology identifying metabolic signatures for longevity suggests that amino-acid pools may be important in longevity. Aging in Caenorhabditis elegans seems to be intimately tied to the modulation of metabolism. The first genes identified for their ability to affect life span were age-1 which encodes a phosphatidylinositol kinase 1 and daf-2 constitutive dauer formation which encodes a receptor tyrosine kinase similar to the mammalian insulin and insulin-like growth factor 1 IGF1 receptors 2 . Although complete loss of daf-2 function is lethal 3 partial loss of function extends adult life by two- to threefold. daf-2 and age-1 specify steps in the insulin insulin-like signaling IIS pathway thereby influencing metabolism. IIS signaling inactivates the FOXO forkhead box O transcription factor DAF-16 which controls genes that mediate a wide variety of functions including metabolism innate immunity stress response and translation reviewed in 4 . The modulation of life span by the IIS pathway seems to result from an intricate network of physiological changes primarily mediated by unregulated DAF-16 activity including major shifts in both energy and fat metabolism. In addition to the IIS pathway two other main groups of genes have profound effects on life span and are linked to metabolic control genes involved in dietary restriction Correspondence driddle@ Department of Medical Genetics Faculty of Medicine 263-2185 East Mall The University of British Columbia Vancouver BC V6T