tailieunhanh - Báo cáo sinh học: "Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology. | Journal of Biology Minireview Forward genetics in Tribolium castaneum opening new avenues of research in arthropod biology Andrew D Peel Address Institute of Molecular Biology and Biotechnology IMBB Foundation for Research and Technology Hellas FoRTH Nikolaou Plastira 100 GR-70013 Iraklio Crete Greece. Email apeel@ Abstract A recent paper in BMC Biology reports the first large-scale insertional mutagenesis screen in a non-drosophilid insect the red flour beetle Tribolium castaneum. This screen marks the beginning of a non-biased forward genetics approach to the study of genetic mechanisms operating in Tribolium. See research article http 1741-7007 7 73 Much of our understanding of the genetic mechanisms operating in arthropods is derived from studies on the genetically tractable and long established laboratory model insect Drosophila melanogaster. However despite the many advantages of using the Drosophila model system it does have some inherent theoretical and practical limitations. Many of the traits that predispose Drosophila to laboratory study - for example its small genome and developmental traits associated with its short generation time - are evolutionarily derived and or atypical of many arthropods. As such it has long been accepted that a greater depth of knowledge from a broader range of arthropods is required to gain a clearer understanding of the ancestry and evolution of arthropod developmental mechanisms. In addition studies on arthropod species that exhibit morphological physiological behavioral or ecological traits absent in Drosophila are often a prerequisite to address a specific theoretical question or practical problem. There has therefore been a pressing need to establish reliable and efficient tools for genetic manipulation in arthropod species that often possess larger genomes than Drosophila or exhibit longer and less amenable life histories. Much progress has been made in recent years. The advent of reverse .