tailieunhanh - Báo cáo sinh học: "The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics. | Journal of Biology Minireview The bacterial pathogen Listeria monocytogenes an emerging model in prokaryotic transcriptomics Pascale Cossart ti and Cristel Archambaud Addresses Institut Pasteur Unité des Interactions Bactéries Cellules Paris F-75015 France. tinserm U604 Paris F-75015 France. ÍINRA USC2020 Paris F-75015 France. Correspondence Pascale Cossart pcossart@ Abstract A major challenge in bacterial pathogenesis is understanding the molecular basis of the switch from saprophytism to virulence. Following a recent whole-genome transcriptomic analysis using tiling arrays an article published in BMC Genomics reports the first use of RNA-seq in Listeria monocytogenes in order to identify genes controlled by sigma B a transcriptional regulator with a critical role in virulence. See research article http 1471-2164 10 641 A fundamental goal in infection biology is to identify the attributes of a pathogen that allow it to establish an infection and the mechanisms whereby this is achieved. Listeria monocytogenes is a soil bacterium that lives in decaying vegetation and can contaminate food products. In healthy individuals L. monocytogenes causes gastroenteritis but in immunocompromised individuals it can cause meningitis with a high mortality rate and in pregnant women it can lead to abortion. It is closely related to Bacillus subtilis which survives adverse conditions by sporulating and although L. monocytogenes does not sporulate it can survive and even replicate in harsh environments including those such as low pH low temperature and high salt that are used to control food contamination. Listeria is ubiquitous in the environment but was discovered only in 1926 as the cause of an epidemic affecting rabbits and guinea pigs in animal-care houses Figure 1 . In the infected host this bacterium is mostly intracellular owing to its capacity to resist macrophage killing and to its exquisite property to invade a variety of non-phagocytic cells .

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