tailieunhanh - Báo cáo sinh học: "Generalized immune activation as a direct result of activated CD4+ T cell killing"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Generalized immune activation as a direct result of activated CD4+ T cell killing. | Journal of Biology BioMed Central Research Open Access Generalized immune activation as a direct result of activated CD4 T cell killing Rute Marques Adam Williams1 Urszula Eksmond Andy Wullaert4 Nigel Killeen Manolis Pasparakis Dimitris Kioussis1 and George Kassiotis Addresses Division of Immunoregulation and tDivision of Molecular Immunology MRC National Institute for Medical Research The Ridgeway London NW7 1AA UK. Institute for Genetics University of Cologne Zulpicher Strasse 47 50674 Cologne Germany. Department of Microbiology and Immunology University of California San Francisco CA 94143 USA. Current address Department of Immunobiology Yale University School of Medicine New Haven CT 06520 USA. Correspondence George Kassiotis. Email gkassio@ Published 27 November 2009 Received 15 September 2009 Revised 6 October 2009 Accepted 7 October 2009 Journal of Biology 2009 8 93 The electronic version of this article is the complete one and can be found online at http content 8 10 93 2009 Marques et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In addition to progressive CD4 T cell immune deficiency HIV infection is characterized by generalized immune activation thought to arise from increased microbial exposure resulting from diminishing immunity. Results Here we report that in a virus-free mouse model conditional ablation of activated CD4 T cells the targets of immunodeficiency viruses accelerates their turnover and produces CD4 T cell immune deficiency. More importantly activated CD4 T cell killing also results in generalized immune activation which is attributable to regulatory CD4 T cell insufficiency and preventable by regulatory CD4 T cell reconstitution. Immune activation