tailieunhanh - Báo cáo sinh học: "Nursing some sense out of Myc"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Nursing some sense out of Myc. | Journal of Biology Minireview Nursing some sense out of Myc Nicole M Sodir and Gerard I Evan Address Department of Pathology and Helen Diller Family Comprehensive Cancer Center University of California San Francisco CA 94143-0502 USA. Correspondence Gerard I Evan. Email Abstract Data recently published in BMC Biology provide insights into the normal physiological function of c-myc in the development and regeneration of the mammary gland and indicate a key role in epithelial cell proliferation elaboration of ductal alveoli and the biosynthetic capacity and milk production of the mature organ. See related research article http 1741-7007 7763 The three Myc proteins c-Myc L-Myc and N-Myc are all basic helix-loop-helix bHLH -Zip transcription factors that coordinate cell proliferation cell cycle progression cell growth metabolism differentiation and tissue remodeling as well as a variety of protective checkpoint mechanisms such as growth arrest and apoptosis. Myc proteins form heterodimers with their bHLH-Zip partner Max transactivating genes by binding at canonical E-Box CACG ATG recognition elements in target gene promoters and repressing other genes through interactions with the zinc finger protein Miz-1 and or recruitment of the DNA methyltransferase corepressor Dnmt3a Figure 1 1 . Expression array SAGE chromatin IP promoter scanning and whole cell proteomic approaches identify thousands of Myc target genes with diverse roles in virtually every aspect of cell and tissue behavior including growth metabolism cell cycle differentiation telomere maintenance DNA damage and repair intracellular membrane transport cytoskeleton cytokine production angiogenesis invasion and apoptosis 2 see also http site . In normal cells expression of Myc proteins is tightly regulated either by developmental cues or in the case of c-Myc expression in adult regenerative tissues by mitogenic stimulation. In the