tailieunhanh - Báo cáo sinh học: "The complex genetic basis of simple behavio"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The complex genetic basis of simple behavior. | Journal of Biology Minireview The complex genetic basis of simple behavior Anna J Jasinska and Nelson B Freimer Address Center for Neurobehavioral Genetics University of California Los Angeles CA 90095 USA. Correspondence Nelson B Freimer. Email nfreimer@ Abstract Genetic approaches to dissecting complex traits in animal models increasingly use transcript levels as a molecular phenotype and as validation for predictions of gene function. A recent study in BMC Biology using these approaches shows the complexity of the genetic contribution to aggressive behavior in Drosophila. Genetic investigation of quantitative behavioral traits Neuropsychiatric geneticists are now focusing considerable attention on the investigation of quantitative human behavioral traits postulating that such phenotypes could be more straightforward to genetically map than neuropsychiatric disorders. Such syndromes are among the most complex of human traits a fact that may explain why efforts to elucidate their etiology have been singularly unsuccessful. Although quantitative phenotypes may be simpler than clinically heterogeneous diseases there is still little evidence that human behavioral quantitative trait loci QTL will be easy to identify. For this reason there is a tremendous appeal in using the powerful tools available for genetic investigation of simple model organisms genes implicated in behavioral variation in flies or worms can then be targeted for various forms of analysis in mammals including humans. This strategy depends on the identification of suitable measures of behavior in simple systems. Circadian rhythms are a classic example. Investigations of clock mutants in Drosophila led to the discovery of the first circadian rhythm gene period and ultimately to cellular pathways underlying circadian behavior 1 this line of investigation was subsequently successfully extended in rodents as well as humans 2 . Aggressive behavior is another complex behavioral trait that .