tailieunhanh - Báo cáo sinh học: "Transcription in mosquito hemocytes in response to pathogen exposure"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Transcription in mosquito hemocytes in response to pathogen exposure. | Journal of Biology BloMed Central Minireview Transcription in mosquito hemocytes in response to pathogen exposure Julián F Hillyer Address Department of Biological Sciences and Institute for Global Health Vanderbilt University VU Station B 35-1634 Nashville TN 37235-1634 USA. Email Published 5 June2009 Journal of Biology 2009 8 51 doi jbiol151 The electronic version of this article is the complete one and can be found online at http content 8 5 51 2009 BioMed Central Ltd Abstract Mosquito hemocytes are blood cells that are fundamental for combating systemic infection. A study published in BMC Genomics shows that hemocyte gene transcription in response to immune challenge is pathogen-specific and reaffirms the primary role of these cells in immunity. Mosquitoes and microbes Throughout their lifetime mosquitoes are in danger of acquiring deadly pathogens. During their egg larval and pupal stages mosquitoes live in aquatic environments that are often rife with bacteria. Culex pipiens for instance thrive in sewer systems. As adults mosquitoes often lose their legs creating openings by which pathogens can enter their body. Female mosquitoes also engage in the dangerous behavior of biting vertebrates and ingesting their blood. This is done to acquire the nutrients necessary for the production of large numbers of eggs but it exposes mosquitoes to bloodborne pathogens such as Plasmodium filarial nematodes and arboviruses. Besides being deadly and debilitating to humans these organisms are pathogenic to mosquitoes if acquired in high enough numbers. So how does a mosquito respond to a microbial pathogen When a foreign invader enters the body cavity of a mosquito it elicits a systemic immune response. Similarly to that of vertebrates this immune response has both humoral and cellular components. However the invertebrate response lacks the properties of somatic hypermutation and immune memory that are hallmarks of vertebrate .

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