tailieunhanh - Báo cáo sinh học : " Louis Du Pasquier"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Louis Du Pasquier. | Journal of Biology BloMed Central Minireview Fish n TRIMs Louis Du Pasquier Address University of Basel Institute of Zoology and Evolutionary Biology Vesalgasse 1 CH-4051 Basel Switzerland. Email dupasquier@ Published 29 May 2009 Journal of Biology 2009 8 50 doi jbiol150 The electronic version of this article is the complete one and can be found online at http content 8 5 50 2009 BioMed Central Ltd Abstract A novel diversified multigene family of tripartite-motif TRIM intracellular receptors with putative antiviral activity has been identified in teleost fish and published in BMC Biology. The history of these receptors involves ancient linkage to paralogs of the major histocompatibility complex and the family has invertebrate precursors. Multigene families are common in metazoa. They result from genomic duplications and contain a variety of genes such as those encoding the immunoglobulin superfamily cadherins leucine-rich repeats scavenger receptors actins tubulins keratins collagens heat shock proteins and rhodopsins. The largest receptor families which can contain tens to hundreds of members comprise mostly either olfactory receptors of the rhodopsin family or immunoreceptors such as cysteine-rich scavenger receptors SRCRs and Toll-like receptors TLRs in echinoderms and the nucleotide-binding and oligomerization domain leucine-rich repeat receptors also known as NOD-like receptors or NLRs in teleosts as well as other immunoglobulin superfamily members in teleosts amphibians birds and mammals 1 . In such families the immunologist sees a potential source of useful diversity for innate immune recognition and immediately thinks in terms of its adaptive value. The evolutionary biologist reminds us that not all diversity is adaptive and asks for direct evidence of involvement in immunity. At this point the cell biologist confronts the difficult issue of how the expression of large sets of genes is controlled. Tripartite-motif TRIM .