tailieunhanh - Báo cáo sinh học: " CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. | J. Biol. Journal of Biology BioMed Central Research article Open Access CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo Joerg Dietrich Ruolan Han Yin Yang Margot Mayer-Proschel and Mark Noble Address Department of Biomedical Genetics University of Rochester Medical Center 601 Elmwood Avenue Rochester NY 14642 USA. These authors contributed equally to this work Correspondence Mark Noble. Email mark_noble@ Received 27 March 2006 Revised 23 June 2006 Accepted 6 October Published 30 November 2006 Journal of Biology 2006 5 22 The electronic version of this article is the complete one and can be found online at http content 5 7 22 2006 Dietrich et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chemotherapy in cancer patients can be associated with serious short- and long-term adverse neurological effects such as leukoencephalopathy and cognitive impairment even when therapy is delivered systemically. The underlying cellular basis for these adverse effects is poorly understood. Results We found that three mainstream chemotherapeutic agents - carmustine BCNU cisplatin and cytosine arabinoside cytarabine representing two DNA cross-linking agents and an antimetabolite respectively - applied at clinically relevant exposure levels to cultured cells are more toxic for the progenitor cells of the CNS and for nondividing oligodendrocytes than they are for multiple cancer cell lines. Enhancement of cell death and suppression of cell division were seen in vitro and in vivo. When administered systemically in mice these chemotherapeutic agents were associated with increased cell death and decreased cell division in the subventricular .