tailieunhanh - Báo cáo y học: " Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven. | Method Open Access Detecting transcriptionally active regions using genomic tiling arrays Gabor Halasz Marinus F van Batenburg Joelle Perusse Sujun Hua Xiang-Jun Lu Kevin P White and Harmen J Bussemaker Addresses Department of Biological Sciences Columbia University 1212 Amsterdam Avenue New York NY 10027 USA. Integrated Program in Cellular Molecular and Biophysical Studies Columbia University 630 w. 168th Street New York NY 10032 USA. Bioinformatics Laboratory Academic Medical Center University of Amsterdam Meibergdreef 15 1105 AZ Amsterdam The Netherlands. Department of Genetics Yale University School of Medicine 333 Cedar Street PO Box 208005 New Haven CT 06520-8005 USA. Department of Ecology and Evolutionary Biology Yale University 165 Prospect Street PO Box 208106 New Haven CT 06250-8106 USA. Center for Computational Biology and Bioinformatics Columbia University 1130 St. Nicholas Avenue New York NY USA. Correspondence Harmen J Bussemaker. Email hjb2004@ Published 19 July 2006 Genome Biology 2006 7 R59 doi 186 gb-2006-7-7-r59 The electronic version of this article is the complete one and can be found online at http 2006 7 7 R59 Received 26 September 2005 Revised 5 January 2006 Accepted 5 July 2006 2006 Halasz et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We have developed a method for interpreting genomic tiling array data implemented as the program Transcription Detector. Probed loci expressed above background are identified by combining replicates in a way that makes minimal assumptions about the data. We performed medium-resolution Anopheles gambiae tiling array experiments and found extensive transcription of both coding and non-coding regions. Our method also .