tailieunhanh - Báo cáo y học: "Signatures of human regulatory T cells: an encounter with old friends and new"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Signatures of human regulatory T cells: an encounter with old friends and new. | Research Open Access Signatures of human regulatory T cells an encounter with old friends and new players Susanne Pfoertner Andreas Jeron Michael Probst-Kepper Carlos A Guzman Wiebke Hansen Astrid M Westendorf Tanja Toepfer Andres J Schrader Anke Franzke Jan Buer and Robert Geffers Addresses Department of Mucosal Immunity German Research Centre for Biotechnology Braunschweig Germany. Volkswagen Foundation Junior Research Group Department of Visceral and Transplant Surgery Hanover Medical School Hanover Germany. Department of Vaccinology German Research Centre for Biotechnology Braunschweig Germany. Department of Urology Philipps-University Medical School Marburg Germany. Department of Hematology and Oncology Hanover Medical School Hanover Germany. Institute of Medical Microbiology Hanover Medical School Hanover Germany. Correspondence Jan Buer. Email jab@ Published 12 July 2006 Genome Biology 2006 7 R54 doi 186 gb-2006-7-7-r54 The electronic version of this article is the complete one and can be found online at http 2006 7 7 R54 Received 6 March 2006 Revised 16 May 2006 Accepted 2 June 2006 2006 Pfoertner et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Naturally occurring CD4 CD25 regulatory T cells TReg are involved in the control of autoimmune diseases transplantation tolerance and anti-tumor immunity. Thus far genomic studies on TReg cells were restricted to murine systems and requirements for their development maintenance and mode of action in humans are poorly defined. Results To improve characterization of human TReg cells we compiled a unique microarray consisting of 350 TReg cell associated genes Human TReg Chip based on whole genome transcription data from .