tailieunhanh - Báo cáo y học: "Immunological applications of genomics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Immunological applications of genomics. | Meeting report Immunological applications of genomics Silvia Monticelli Sonia Sharma and Anjana Rao Address Harvard Medical School and the CBR Institute for Biomedical Research Boston MA 02115 USA. Correspondence Silvia Monticelli. Email monticel@ Published 25 July 2006 Genome Biology 2006 7 321 doi gb-2006-7-7-321 The electronic version of this article is the complete one and can be found online at http 2006 7 7 321 2006 BioMed Central Ltd A report of the Cold Spring Harbor Laboratory meeting Gene Expression and Signaling in the Immune System Cold Spring Harbor New York USA 26-30 April 2006. The 2006 meeting on Gene Expression and Signaling in the Immune System at the Cold Spring Harbor Laboratory highlighted diverse aspects of signal transduction and transcriptional regulation in lymphocytes and other hematopoietic cells. We shall discuss some of the highlights of the meeting focusing on research related to relying on or informed in some way by genomics including studies of long-range interactions between cis- and even trans-regulatory regions genome-wide transcriptional profiling and RNAi screens epigenomic analysis and the use of RNA interference RNAi and microRNAs miRNA to study gene expression. Long-range gene regulation The expression of immune-system genes is under strict control with many of the crucial gene regulatory elements lying outside the proximal promoter regions. A number of presentations explored these distal regulatory regions and the proteins that interact with them. The specification of cell fate during the development of T lymphocytes in the thymus is associated with the differential expression of the CD4 and CD8 cell-surface co-receptor proteins which mark two main lineages of T cells the helper and killer cytolytic T cells respectively. Expression of CD4 and CD8 is tightly controlled by cis-regulatory elements that function in a developmental stage-specific subset-specific and lineagespecific .

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