tailieunhanh - Báo cáo y học: "Distinct patterns of SSR distribution in the Arabidopsis thaliana and rice genomes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Distinct patterns of SSR distribution in the Arabidopsis thaliana and rice genomes. | Research Open Access Distinct patterns of SSR distribution in the Arabidopsis thaliana and rice genomes Mark J Lawson and Liqing Zhang Address Department of Computer Science Virginia Tech 655 McBryde Blacksburg VA 24060 USA. Correspondence LiqingZhang. Email lqzhang@ Published 21 February 2006 Genome Biology 2006 7 RI4 doi I86 gb-2006-7-2-rI4 The electronic version of this article is the complete one and can be found online at http 2006 7 2 RI4 Received 26 August 2005 Revised 26 October 2005 Accepted 30 January 2006 2006 Lawson and Zhang licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Simple sequence repeats SSRs in DNA have been traditionally thought of as functionally unimportant and have been studied mainly as genetic markers. A recent handful of studies have shown however that SSRs in different positions of a gene can play important roles in determining protein function genetic development and regulation of gene expression. We have performed a detailed comparative study of the distribution of SSRs in the sequenced genomes of Arabidopsis thaliana and rice. Results SSRs in different genic regions - 5 untranslated region UTR 3 UTR exon and intron -show distinct patterns of distribution both within and between the two genomes. Especially notable is the much higher density of SSRs in 5 UTRs compared to the other regions and a strong affinity towards trinucleotide repeats in these regions for both rice and Arabidopsis. On a genomic level mononucleotide repeats are the most prevalent type of SSRs in Arabidopsis and trinucleotide repeats are the most prevalent type in rice. Both plants have the same most common mononucleotide A T and dinucleotide AT and AG repeats but have little